Diagnosis

Biological Agents Infliximab (a chimaeric humanised anti-tumour necrosis factor [TNF]-α antibody) was the first TNF-α inhibitor approved for the...

Evidence of Genetic Susceptibility in Disease Pathogenesis There are considerable epidemiological data that implicate genetic susceptibility in the...

Traditional Therapies in Crohn’s Disease Anti-inflammatory drugs and oral immunosuppressants have traditionally been the mainstay for treating...

Mild to Moderate Ulcerative Colitis 5-aminosalicylic acid (5-ASA) has been extensively evaluated and is considered the first-line therapy for mild to...

Structure and Pharmacology of Tumor Necrosis Factor-α Antagonists The unique pharmacologic profiles among the three anti-TNF-α antibodies and their...