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Sunday, 06 July, 2008



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The liver, that great maroon snail: No wave of emotion sweeps it. Neither music nor mathematics gives it pause in its appointed tasks

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Dr. Richard Selzer
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Editor's featured articles published within Hepatic Disorders

Liver Fibrogenesis Evolving Concepts of Liver Fibrogenesis Provide New Diagnostic and Therapeutic Options
Despite intensive studies, the clinical opportunities for patients with fibrosing liver diseases have not improved. This will be changed by increasing knowledge of new pathogenetic mechanisms, which complement the "canonical principle" of fibrogenesis.
F Fred Poordad Hepatitis C – Evolution of Therapy
Hepatitis C virus (HCV) infection affects roughly 3% of the world’s population,1,2 and is the main indication for liver transplantation in the US and Europe. Therapy for hepatitis C has evolved relatively quickly over the past 16 years.
Management Roadmap for Treatment-Naive Patients Chronic Hepatitis B Virus—Treating Patients to Prevent and Manage Resistance
The risk of resistance or the development of resistance to antiviral agents during the treatment of chronic hepatitis B (CHB) infection presents the clinician with a number of hurdles. Due to the known complications that can occur once resistance emerges.
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What Change Does Prokineticin 2/Bv8 Have In Human Hepatocellular Carcinoma?
Liver hepatocarcinoma is a highly vascularized cancer, and more and more research is focused on the molecules controlling angiogenesis. In 2001, two novel peptides, known as prokineticin 1/EG-VEGF (PK1/EG-VEGF) and prokineticin 2/Bv8 (PK2/Bv8), were identified, as having potent angiogenic activities. The angiogenic potential of these two peptides during human hepatocellular carcinoma progression was evaluated. These findings show, that only, PK2/Bv8 is expressed in liver and -- surprisingly -- that its expression decreases during hepatocellular carcinoma. read more...

Living Donor Liver Transplants Improved Outcome Using New Technique
The University of Alberta Hospital (UAH) is one of only a few centers in Canada that perform living donor liver transplantation, a surgical procedure developed in the late 1980s that expands the organ donor pool. About 80 liver transplants are done a year in Alberta, 10 of those being living-donor. All potential liver transplant donors are assessed based on considerations such as the size and composition of the liver and vascular and bile duct anatomy. read more...


Guidelines Watch
A round up of the latest Clinical Guidelines from the National Guideline Clearinghouse (NGC)

Hepatitis A: 1) Immunizations. 2) Immunization update.
Institute for Clinical Systems Improvement - Private Nonprofit Organization. 2007 Oct (addendum released 2007 Dec). Original guideline: 61 pages; Addendum: 4 pages. NGC:006222

Adult preventive health care: immunizations.
University of Michigan Health System - Academic Institution. 2004 May (revised 2007 Mar). 9 pages. NGC:005676


Featured Association
A Message from Dr. Kang, Founding President of ILTS

Liver transplantation was developed to treat patients with end-stage liver disease with exactly what was needed, a new liver, through an exceptionally straightforward procedure (Thomas Starzl). However, liver transplantation is a complex process with high morbidity and mortality. These problems are associated with a number of inter-related issues: the multiple organ dysfunction often seen in patients with end-stage liver disease, the lengthy sophisticated surgical procedures, the quality of the donor organ, the systemic effects of the anhepatic state, and postoperative complications including graft nonfunction, rejection, infection, and other long-term care related issues.

It was recognized that liver transplantation cannot be handled by a small number of physicians, but rather requires the collective and collaborative participation and expertise of physicians and scientists from diverse fields. As a result, the International Liver Transplantation Society (ILTS) was founded by a group of committed individuals at the liver transplantation meeting in Pittsburgh in 1990. From these initial efforts to the present, the goal of the Society has been to raise the standard of care for patients requiring liver transplantation and to promote education and research by disseminating and exchanging information related to liver transplantation within the medicalcommunity, as well as to the public. This young multidisciplinary society has done a remarkable job of fulfilling its goals through biennial congresses, (the Third in conjunction with LICAGE), its official journal (Liver Transplantation and Surgery), courses with the American Association for the Study of Liver Diseases and at the American Society of Anesthesiology meetings, and quarterly newsletters. The ILTS Web Page is a natural extension of the Society's function. The ILTS hopes that this page will provide a venue for formal and informal discussions and information exchanges relevant to liver transplantation among ILTS members and other interested parties.

Yoogoo Kang, M.D.
Founding President, ILTS
Department of Anesthesiology
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania USA



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