Articles
A 47-year-old man with neuro-Sweet syndrome in association with Crohn’s disease: a case report
Introduction Sweet’s syndrome is a multi-system neutrophilic disease first described by Dr. Robert Douglas Sweet in 1964 [1] and is also known as...
Advances in the Treatment of Crohn’s Disease and Ulcerative Colitis
Biologic therapeutic strategies that have been tested or are still partly under investigation in multicentre studies include inhibitors of...
Are All Anti-tumor Necrosis Factor Antibodies the Same in Crohn’s Disease?—A Systematic Review with Commentary
Structure and Pharmacology of Tumor Necrosis Factor-α Antagonists The unique pharmacologic profiles among the three anti-TNF-α antibodies and their...
Can Antidepressants Influence the Course of Inflammatory Bowel Disease? The Current State of Research
Inflammatory bowel disease (IBD) is a generic term used to describe a group of chronic and relapsing inflammatory disorders of the gastrointestinal...
Certolizumab Pegol in Crohn’s Disease
Traditional Therapies in Crohn’s Disease Anti-inflammatory drugs and oral immunosuppressants have traditionally been the mainstay for treating...
Colonic Drug Delivery Challenges and Oppor tunities - An Overview
The overall goal for optimum therapy is to match the needs of the patient while improving the efficiency and safety of the administered drugs....
Endoscopic Healing as a Therapeutic Target in Crohn’s Disease
Historically, the treatment goals for Crohn’s disease were mainly palliative: to improve symptoms and induce and maintain clinical response and...
Fifty Years of the World Gastroenterology Organisation
In parallel with these organizational developments, the field of gastroenterology itself has witnessed tremendous progress. Who could have envisaged...
Genetics of Inflammatory Bowel Disease
Evidence of Genetic Susceptibility in Disease Pathogenesis There are considerable epidemiological data that implicate genetic susceptibility in the...
Improving Mucosal Barrier Function - A Novel Therapeutic Strategy for Crohns Disease
The intestinal mucosal barrier is composed of not only the mucosal epithelium, but also a highly integrated immune system. Recent evidence suggests...
Infection, Antibiotic Use, and the Development of Crohn s Disease
Reference Section Infection, Antibiotic Use, and the Development of Crohnýs Disease B USINESS BRIEFING: US GASTROENTEROLOGY REVIEW...
New Developments in the Management of Steroid-refractory Inflammatory Bowel Disease
The advancements in the current immunomodulatory or biological therapies for IBD reflect the exponential advancement in the understanding of the...
Optimising Biologic Therapies for Maximal Effect in Crohn s Disease
Overview of Pivotal Anti-tumour Necrosis Factor Trials Infliximab was the first and has been the most extensive anti-TNF agent evaluated in the...
Second-line Medical Therapy for Acute Severe Ulcerative Colitis – Saving Colons or Risking Lives?
It is clear that 30–40% of patients will not respond to corticosteroid therapy, and the current standard of care for these patients remains urgent...
The Effects of Treatment on Histology in Inflammatory Bowel Disease
Changes in IBD Histology with Time and Treatment The traditional description of UC is that of a disease affecting the rectum and extending to a...
The Most Significant Advances in the Management of Crohn’s Disease
Biological Agents Infliximab (a chimaeric humanised anti-tumour necrosis factor [TNF]-α antibody) was the first TNF-α inhibitor approved for the...
The Role of Alvimopan in Potentially Reducing Patient Recovery Times After Bowel Surgery
Whether or not intestinal resection is performed, the first 24–72 postoperative hours are accompanied by a lack of peristalsis and later by...
The Role of Inflammation in the Course of Crohn s Disease
In 1932, Crohn, Ginzburg and Oppenheimer accurately described, from resected specimens, the homogeneous picture of a sub-acute or chronic...
The Role of Mucosal Healing in the Treatment of Crohn s Disease and Ulcerative Colitis
More important, ulcerations are at the origin of complications as fistula tracts, bacterial translocation leading to abscess formation and/or toxic...
The Role of Serological Testing in the Diagnosis and Management of Patients with Inflammatory Bowel Disease
Serology TestingSeveral experimental animal models of IBD have led to the theory that the pathogenesis of IBD is the result of an aberrant immune...
